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src kinase-specific inhibitor pp1  (Biomol GmbH)

 
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    Biomol GmbH src kinase-specific inhibitor pp1
    Src Kinase Specific Inhibitor Pp1, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/src+kinase-specific+inhibitor+pp1/src+kinase+inhibitors+pp1+and+pp2/pm29079540-32-36-42
    Average 90 stars, based on 1 article reviews
    src kinase-specific inhibitor pp1 - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Binding Assay:

    Article Title: IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction.
    Article Snippet: Glial cell hyperactivity has been proposed to be responsible for chronic pain, however, the mechanisms remain unclear.. Interleukin (IL)-18, released from glial cells, has been reported to be involved in neuropathic pain.. In this study, we investigated the role of IL-18 in bone cancer pain.

    Recombinant:

    Article Title: IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction.
    Article Snippet: Glial cell hyperactivity has been proposed to be responsible for chronic pain, however, the mechanisms remain unclear.. Interleukin (IL)-18, released from glial cells, has been reported to be involved in neuropathic pain.. In this study, we investigated the role of IL-18 in bone cancer pain.



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    Inhibition of protein tyrosine kinase activity blocks TCR down-regulation. P14 TCR transgenic spleen cells (A, B) or P14.G5 CTL clone (C, D) were preincubated for 60 min in the presence of PP1 or genistein. Preincubation with herbimycin A was done overnight with P14 spleen cells or for 60 min with P14.G5 CTL. EL-4 cells pulsed with p33 (1 μM) were then added for 4 h and cells stained for flow cytometry with anti-CD8 and anti-Vα2 antibodies (A, C) or with anti-CD8 and anti-CD69 antibodies (B, D). Mean fluorescence intensities are expressed as % or MFI of control in the absence of peptide.

    Journal:

    Article Title: Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation

    doi:

    Figure Lengend Snippet: Inhibition of protein tyrosine kinase activity blocks TCR down-regulation. P14 TCR transgenic spleen cells (A, B) or P14.G5 CTL clone (C, D) were preincubated for 60 min in the presence of PP1 or genistein. Preincubation with herbimycin A was done overnight with P14 spleen cells or for 60 min with P14.G5 CTL. EL-4 cells pulsed with p33 (1 μM) were then added for 4 h and cells stained for flow cytometry with anti-CD8 and anti-Vα2 antibodies (A, C) or with anti-CD8 and anti-CD69 antibodies (B, D). Mean fluorescence intensities are expressed as % or MFI of control in the absence of peptide.

    Article Snippet: 4.13 Inhibition of src family kinase activity P14.G5 CTL (6×10 4 /well) or P14 spleen cells (5×10 5 /well) were preincubated for 60 min with the src family kinase-specific inhibitor PP1 (10 μM and 50 μM, respectively) (Bio-mol, Plymouth Meeting, PA) [ 28 ].

    Techniques: Inhibition, Activity Assay, Transgenic Assay, Staining, Flow Cytometry, Fluorescence, Control